Inflammatory Myopathies

Introduction

Inflammatory myopathies are a group of rare diseases that cause muscle inflammation and weakness. They are autoimmune diseases. Common types include polymyositis, dermatomyositis and Inclusion body myositis.

What are the features of Inflammatory Myopathies?

  1. Polymyositis is a rare disease
  2. Ocular and facial muscle weakness present in polymyositis
  3. Dermatomyositis occurs in children and adults
  4. Inclusion body myositis (IBM) present in 30-to-40 year of age
  5. Serum creatine phosphokinase (CPK) level may be normal

Bohan & Peter Diagnostic Criteria For Dermatomyositis / Polymyositis

  1. Symmetric proximal muscle weakness
  2. Elevated muscle enzyme creatine phosphokinase (CPK) levels
  3. A myopathic pattern on electromyogram (EMG)
  4. Evidence of an endomysial, mononuclear inflammatory infiltrate on muscle biopsy
  5. Characteristic skin rash of dermatomyositis (Heliotrope rash or Gottron’s papules)
For Definite Polymyositis:
  • All first four criteria must be present
For Definite Dermatomyositis:
  • Characteristic rash along with three other criteria must be present

Polymyositis

  • It is a rare disease.
  • Incidence: Less than 25 per 100000 population
  • Age: It usually develops between the ages of 30-to-60.
  • Facial and extraocular muscle involvement is not a characteristic of polymyositis.

Dermatomyositis

  • Dermatomyositis can occur in both children and adults.
  • Children: Between the ages of 5 and 15.
  • Adults: Between the ages of 40 and 60.

Inclusion Body Myositis

  • It mostly occurs over 50 years of age.

Answer(s)

  1. Polymyositis is a rare disease-True
  2. Ocular and facial muscle weakness present in polymyositis-False
  3. Dermatomyositis occurs in children and adults-True
  4. Inclusion body myositis (IBM) present in 30-to-40 year of age-False
  5. Serum creatine phosphokinase (CPK) level may be normal-False

Bonus Pearls:

Do you know! characteristic skin rash is must to diagnose dermatomyositis.

I hope you like this post. If you want to read more such articles, then definitely let us know through your comments in the comment box. Your feedback is valuable. If you find any mistakes in this article, please inform us through the comments, so that we can provide good information with corrections in the next blog post.

Feedback:

What is your view on this topic? Let us know your answer(s) in the comments below! Leave a Comment!

Location: India

Comments

Post a Comment

Popular posts from this blog

Blood Supply of Spinal Cord

How many spinal arteries supply the human spinal cord? Three Arteries Four Arteries Five Arteries Two Arteries Blood Supply of Spinal Cord Arterial Supply The spinal cord is supplied by Three Longitudinal Arteries : One Anterior Spinal Artery supplies the anterior two-thirds of the spinal cord. Two Posterior Spinal Arteries supply the posterior one-third of the spinal cord. [Mnemonics: Posterior is Paired, Posterior = Paired] Venous Drainage There is a complex network of intrinsic, extrinsic, and extradural systems. The anterior and posterior spinal veins and anterior and posterior radicular veins are freely communicate with the internal vertebral plexus in the epidural space. This drains into the cerebral dural venous sinuses and cerebral veins as well as the external vertebral plexus. The veins of the spinal cord and vertebral column are valveless. Reference: Bosmia AN, Hogan E, Loukas M, Tubbs RS, Cohen‐Gadol AA. Blood supply to the human spinal cord: part ...
Read more

Neurology: Self-Assessment

Image
✍️ Neurology: Self-Assessment || Stroke || Part 02 || Dear Neurology Aspirants! Please! Watch the video for Self-Assessment. The assessment video contains 30 questions from the Chapter: Stroke. The video used objective questions from “The Neurology: Self-Assessment & Review" by Dr. Sunil Kumar. Hope! This will help you to manage your time in the examination hall. Best of Luck!
Read more

Cerebellar Historical Facts

✍️ Introduction: When you try to kiss someone, do you know which brain part decides the speed, distance and force of lip movement during a kiss? The best kiss is nothing but a fine coordinated movement of orbicularis oris muscle. Now you are thinking, who controls the coordinated movement of the lip? It is cerebellum! ✍️ Question: Who said - “rate, range, and force of movement is governed by the cerebellum. Sir Joseph Babinski Gillman & Gillman Gordon Holmes Sir Charcot ✍️ Explanation: The cerebellum monitors the rate, range, and force of the movement. The cerebellar diseases do not cause motor weakness but it produces unilateral in-coordination. According to Gordon Holmes, cerebellum controls the “rate, range, and force” of movement. ✍️ Answer(s): 3. Gordon Holmes ✍️ Reference: Holmes, Gordon. “The Croonian Lectures on the Clinical Symptoms of Cerebellar Disease and Their Interpretation. Lecture II. 1922.” Cerebellum (London, England), vol. 6, no. 2, 2007, pp. 148–53; discussion...
Read more